A systemic disease is lurking inside the church that is derailing it from what God intended it to be, to know, and to do. That disease is practical ignorance and isolation. If the church is to be healthy and thriving, its members must gain the needed know-how and skillsets to meaningfully engage with their increasingly difficult-to-reach unsaved neighbors, communities, and cultures in productive conversations about the good news of Jesus Christ. In other words, there must be a re-missioning of the body of Christ.